6-(2,6-二甲基苯基)-2-[[4-(4-甲基-1-哌嗪基)苯基]氨基]-嘧啶并[5',4':5,6]嘧啶并[1,2-A]苯并咪唑-5(6H)-酮
PyriMido[5',4':5,6]pyriMido[1,2-a]benziMidazol-5(6H)-one, 6-(2,6-diMethylphenyl)-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]-
CAS: 847950-09-8
Molecular Formula: C31H30N8O
6-(2,6-二甲基苯基)-2-[[4-(4-甲基-1-哌嗪基)苯基]氨基]-嘧啶并[5',4':5,6]嘧啶并[1,2-A]苯并咪唑-5(6H)-酮 - Names and Identifiers
| Name | PyriMido[5',4':5,6]pyriMido[1,2-a]benziMidazol-5(6H)-one, 6-(2,6-diMethylphenyl)-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]- |
| Synonyms | Lck Inhibitor |
| CAS | 847950-09-8 |
6-(2,6-二甲基苯基)-2-[[4-(4-甲基-1-哌嗪基)苯基]氨基]-嘧啶并[5',4':5,6]嘧啶并[1,2-A]苯并咪唑-5(6H)-酮 - Physico-chemical Properties
| Molecular Formula | C31H30N8O |
| Molar Mass | 530.62 |
| Density | 1.36±0.1 g/cm3(Predicted) |
| Boling Point | 809.1±75.0 °C(Predicted) |
| pKa | 7.87±0.42(Predicted) |
| Storage Condition | 2-8℃ |
| In vitro study | Lck Inhibitor (compound 25) exhibits good potency in the T-cell receptor-induced IL-2 secretion assay (IL-2, IC 50 =0.46 μM) and also inhibits subsequent T-cell proliferation (T-cell prolif, IC 50 =0.53 μM) in the same human T-cells. Lck Inhibitor also inhibits a human mixed lymphocyte reaction (huMLR) with a 10-fold increase in potency as compared to the other invitro cell assays utilizing purified human cells. Lck Inhibitor also displays inhibition of a mechanism-based biochemical cell assay probing Lck-dependent TCR-chain phosphorylation (TCR-chain). Lck Inhibitor shows a 10-fold reduction in potency when IL-2 is induced in a receptor-independent fashion by stimulating with phorbo lester and calcium ionophore (PMA/iono). Lck Inhibitor exhibits a similar level of potency when tested in a general proliferation assay using the human T-cell line, Jurkat (JKT). |
6-(2,6-二甲基苯基)-2-[[4-(4-甲基-1-哌嗪基)苯基]氨基]-嘧啶并[5',4':5,6]嘧啶并[1,2-A]苯并咪唑-5(6H)-酮 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.885 ml | 9.423 ml | 18.846 ml |
| 5 mM | 0.377 ml | 1.885 ml | 3.769 ml |
| 10 mM | 0.188 ml | 0.942 ml | 1.885 ml |
| 5 mM | 0.038 ml | 0.188 ml | 0.377 ml |
Last Update：2024-01-02 23:10:35
![6-(2,6-二甲基苯基)-2-[[4-(4-甲基-1-哌嗪基)苯基]氨基]-嘧啶并[5',4':5,6]嘧啶并[1,2-A]苯并咪唑-5(6H)-酮](http://res.chembk.com/assets/str/2d/8/84/847950-09-8.png)
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View History
6-(2,6-二甲基苯基)-2-[[4-(4-甲基-1-哌嗪基)苯基]氨基]-嘧啶并[5',4':5,6]嘧啶并[1,2-A]苯并咪唑-5(6H)-酮
1-{双环[2.2.1]庚烷-2-基}乙-1-酮
7-氟咪唑并[1,2-a]吡啶-2-羧酸
2-氨基苯硼酸频哪醇酯
反式-3-苯甲酰氧基可替宁2,3,4-三-O-乙酰基-N-Β-D-葡糖苷酸甲酯溴化物
(Bromomethyl)chlorodimethylsilane,(Bromomethyl)dimethylchlorosilane, BMDMCS
6-氯-2-甲基-3-溴咪唑并[1,2-B]哒嗪
(S)-2-(4-硝基苯基)吗啉-4-羧酸叔丁酯
塞利凡诺夫试剂
(4-吡啶-1-基环己基)胺二盐酸盐
1-{双环[2.2.1]庚烷-2-基}乙-1-酮
7-氟咪唑并[1,2-a]吡啶-2-羧酸
2-氨基苯硼酸频哪醇酯
反式-3-苯甲酰氧基可替宁2,3,4-三-O-乙酰基-N-Β-D-葡糖苷酸甲酯溴化物
(Bromomethyl)chlorodimethylsilane,(Bromomethyl)dimethylchlorosilane, BMDMCS
6-氯-2-甲基-3-溴咪唑并[1,2-B]哒嗪
(S)-2-(4-硝基苯基)吗啉-4-羧酸叔丁酯
塞利凡诺夫试剂
(4-吡啶-1-基环己基)胺二盐酸盐